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Furthermore, uncontrolled lytic cell death can cause tissue injury and severe diseases, including acute respiratory distress syndrome (ARDS), neurodegenerative diseases, and inflammatory diseases (62)

Plasmin is a naturally occurring enzyme in the body that breaks down thrombi by degrading both VWF and fibrin

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Expression of proinflammatory genes during estrogen-induced inflammation of the rat prostate

Small-angle X-ray scattering, rheological techniques, laser scanning confocal fluorescence microscopy, and in vitro release studies showed that the addition of an appropriate amount of lipophilic drug to the hexagonal phase liquid crystal gel enhanced the permeability of the hydrophilic drug while slowing down the release of both drugs, thereby prolonging the drug retention time and improving local bioavailability (179)